篇名:
臺灣豬隻鷺山病毒之血清學監測及人工感染試驗Serological surveillance and experimental infection of sagiyama virus in pigs in Taiwan
作者:
黃天祥;李淑慧;張家宜;黃金城;鍾明華
中文摘要:
鷺山病毒(Sagiyama virus)首次於 2002 年自苗栗縣某一豬場約九週齡的石頭豬分離出。檢測當年11縣市上市肉豬血清中和抗體結果,陽性率業已高達51%(296/586)。將9頭無鷺山病毒抗體之12週齡豬隻分成兩組,第一組7頭,每頭分別肌肉接種鷺山病毒,第二組2 頭,不予接種供同居對照用。試驗結果顯示鷺山病毒對豬隻之病原性極低或無病原性,接種鷺山病毒組豬隻雖於接種後1-2天會有短暫性病毒血症和排毒現象,但經8週同居試驗,同居感染並不成立,顯需藉由病媒蚊的叮咬而傳播感染。
英文摘要:
In 2002, Sagiyama virus was first isolated from pigs located in Miao-Li County, Taiwan. During that year, 586 serum samples of marketing pigs were collected from 11 counties and tested by serum neutralization test. The positive rate of serum antibodies against sagiyama virus was 51% (296/586). In a trial, 9 pigs aged at 12-week old without antibodies against sagiyama virus were divided into two groups. The first group consisted of 7 pigs were inoculated intramuscularly with sagiyama virus suspension, respectively. The second group consisted of 2 pigs were uninfected and housed together with the first group for studying the transmission. During a 2-week observation, all the pigs did not show significant clinical symptoms and special pathological lesions when those infected pigs was sacrificed on the 2,3,5,7 and 10 days post inoculation, respectively. Although the infected pigs developed viremia and shedding infectious virus particles from secretion and excretion for the first 1-2 days post inoculation, the two contact control pigs remained negative in virus isolation and antibody response through the 8-week study.
備註:
年份:西元 2004 年
期別:第 40 期
詳細內容:
鷺山病毒(Sagiyama virus),屬披衣病毒科(Togaviridae)中之阿爾法病毒屬(Alphavirus genus)〔10〕,為一單股正鏈RNA 病毒,基因體長11,698nt﹝9﹞,最早係於1956 年日本研究人員從Culextritaeniorhynchus 蚊蟲分離出來〔7,8〕。本病毒對豬、馬、鳥類和人均具有感受性,經病媒蚊叮咬自然感染後會有抗體產生,但目前只知對馬會有臨床症狀產生,包括發熱、發疹、後腿水腫、顎下淋巴結腫大、白血球輕微減少和病毒血症等〔4,5,6,7〕。台灣首次於 2002 年 6 月底自苗栗縣某一豬場約九週齡的石頭豬同時分離出鷺山病毒、環狀病毒(PCV2)和日本腦炎病毒,將此次豬分離之鷺山病毒之非結構性蛋白(nsP1)和醣蛋白(E1)基因增幅、定序並與其他鷺山病毒株比對結果其相似性均達 96% 以上,其中E1 序列更與台灣衛生署疾病管制局從蚊子分離出之鷺山毒株序列相似性高達99.6%﹝1﹞。本試驗目的即在探討鷺山病毒在田間之污染狀況和對豬隻之病原性。
附件下載:
附件名稱:
臺灣豬隻鷺山病毒
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