篇名:
赤羽病毒在台灣豬隻的自然感染Natural infections of pigs with akabane virus
作者:
黃金城;黃天祥;鄧明中;鍾明華;林士鈺
中文摘要:
赤羽病毒 (Akabane virus) 一直都被認為是只會自然感染草食獸的病原,但是我們發現在台灣的豬群也遭到普便的感染。首先我們從豬病材中 分離到一株赤羽病毒 ( NT-14 ) ,此病毒可以經由口鼻途徑以人工接種方式感染豬隻。感染的豬可從口鼻分泌物中排出低濃度的有感染性的病毒顆粒,但排出的病毒不會藉由接觸而感染同居的豬隻。我們也調查了豬隻對於Akabane 病毒的血清中和抗體盛行率,發覺台灣豬群約75%為抗體陽性,其中以母豬及初生小豬的中和抗體力價最高而20週齡肥育豬抗體力價最低。我們的結果建議豬隻是赤羽病毒自然感染及病毒傳播環中的宿主之一。
英文摘要:
Akabane (AKA) virus is considered a pathogen of herbivores in nature. However, we found that pig populations in fields were infected in Tainwan. Anisolate (NT-14) of AKA virus was obtained from pigs. The NT-14 virus was able to infect pigs by the oronasal route. Subsequently, low levels of infectious virus particles were excreted into the oronasal discharge during the stage of viremia but they were not sufficient to infect new porcine hosts via contact transmission. The prevalence of serum neutralizing antibodies to AKA virus in pig populations was investigated, indicating that approximately 75% of pigs in Taiwan were seropositve. Sows and newborn piglets have the highest titers of neutralizing antibodies. Contrarily, fattening pigs aged at approximately 20 weeks old contained the lowest titers of specific antibodies. Our results suggest that pigs in natural situations are part of the AKA virus transmission cycle.
備註:
年份:西元 2002 年
期別:第 38 期
詳細內容:
Akabane (AKA) virus is a member of the Simbu serogroup of the genus Orthobunyavirus. The virus genome consists of three unique segments of single-stranded negative-sense RNA, large (L), medium (M) and small (S), which differ in size with approximately 7, 4, and 0.86 kb, respectively (Pattnaik and Abraham, 1983; Fenner et al., 1993; Akashi et al., 1997).  AKA virus has demonstrated its replication ability in many kinds of natural host species and in several experimental animals. Based on serological evidence, herbivores including cattle, horses, donkeys, sheep, goats, camels and buffaloes appear to be infected in natural situations (Cybinski et al., 1978; Al-Busaidy et al., 1988). Disease cause by AKA virus in cattle, sheep and goats is associated with stillbirths, abortions, congenital arthrogryposis-hydranencephaly syndrome, and hydranencephaly micrencephaly syndrome (Inaba et al., 1975; harley et al., 1997; Della-Porta et al., 1977; Parsonson et al., 1981; Haughey et al., 1988; Whittington et al., 1988). Outbreaks of the disease resulting in con- genital malformations in ruminants have occurred in Japan, Australia, Israel, Turkey, Korea and Taiwan (Inaba, 1979; Shimshony, 1980; Yonguc et al., 1982; Konno et al., 1982; Liao et al., 1996a; Lee et al., 2002). Experimental animals such as chicken embryos, mice and hamsters are also susceptible to artificial infections and their infection may result in deaths or congenital deformities (Andersen and Campbell, 1978; Nakajima et al., 1979, 1980; McPhee et al., 1984; Konno et al., 1988).  AKA virus is arthropod-borne, replicating in and being transmitted by either mosquitoes or midges (Culicoides). Vector species concerned in virus replication and transmission have been intensely studied. In Austrlia, two species of midge, the Culicoides nubeculosus and C. variipennis (Jennings and Mellor, 1989), have been shown to support virus replication. Virus transmission is also demonstrated to be mediated via the bites of C. brevitarsis and C. nebeculosus (Doherty, 1972; Murray, 1987; Jennings and Mellor, 1989). In Japan, AKA virus was isolated from C. oxystoma (Kurogi et al., 1987) and from mosqutoes, including Aedes vexans and Culex tritaeniorhynchus (Oya et al., 1961).  In 2000, an isolate (NT-14) of AKA virus was obtained from a diseased pig aged at 14 weeks old in Taiwan, which afforded the opportunity to investigate the pathogenicity and seroprevalence of AKA virus in fections in pigs. Our studies revealed that most pigs in Taiwan were seropositive to AKA virus. Especially, sows and finishing pigs were under high risk of infection.
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附件名稱:
赤羽病毒在台灣豬隻的自然感染
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