篇名:
新城雞病免疫計畫保護效力之評估Evaluation of the Protection Efficacy of Newcastle Disease Vaccination Programs
作者:
蔡向榮;林地發
中文摘要:
在本研究中對數種新城雞病(Newcastle disease)之免疫計畫以強毒株攻毒的方式評估其保護效力。在試驗1 中,12 組SPF 雞隻在4 日齡時以ND 活毒(L)或不活化疫苗(K)免疫後,在7 日齡或14 日齡再以活毒(L)或不活化疫苗(K)補強一次,各組在5 週齡時以103 LD50佐藤株ND 病毒株攻毒時都有良好的保護力(80-100%)。在試驗2 及3 中,具有高移行抗體之肉雛雞(在4 日齡時之幾何平均ND血球凝集抑制抗體力價為1:84.5-1:135),部份組別在4日齡同時以活毒及不活化疫苗(L +K) 接種,然後在17 日齡時接種活毒疫苗(L),其他組別則是在4 日齡以活毒疫苗(L)接種後,再在14 日齡以不活化疫苗(K)接種,在17 日齡時再以活毒疫苗(L)接種一次。活毒疫苗皆以點眼的方式接種,不活化疫苗皆以皮下的方式接種。二種疫苗接種計畫在5 週齡攻毒時都有很好的保護效果(80- 100%),但如果在3 週齡或4 週齡攻毒時,後者﹝4(L),14(K),17(L)﹞之保護率(100%)顯著較前者﹝4(L+K),17(L)﹞之保護率為高(50-80%)(p<0.05)。﹝*蔡向榮、林地發。新城雞病免疫計畫保護效力之評估。中華獸醫誌25(1):1-7 1999。*聯絡人TEL:02-23692844,FAX:02-23661475, email: tsaihj@ccms.ntu.edu.tw﹞
英文摘要:
Various Newcastle disease (ND) vaccination programs were tested for their protection efficacy. In trial 1, SPF chicks were vaccinated with an attenuated or inactivated ND vaccine at 4-day-old, then boosted again with an attenuated or inactivated ND vaccine at 7 days of age or 14 days of age. All vaccinated groups showed a good protection rate (80-100%) when they were challenged with a virulent ND virus at 5-week-old. In trials 2 and 3, several groups of broilers with high maternal antibodies (geometric mean hemagglutination-inhibition antibody titer was 1:84.5-1:135 at 4-day-old) were simultaneously immunized with an attenuated and an inactivated ND vaccine at 4 days of age, and then revaccinated with an attenuated ND vaccine at 17-day-old. Other groups of broilers were first vaccinated with a live vaccine at 4-day-old, revaccinated with an inactivated vaccine at 14-day-old, and then boosted again with a live vaccine at 17-day-old. Good protection rate (80-100%) was achieved in both groups when they were challenged at 5-week-old. When they were challenged at 3-week-old and 4-week-old, the latter broiler groups had a significantly higher protection rate (100%) than the formal broiler groups (50-80%)
備註:
年份:西元 1999 年
期別:第 35 期
詳細內容:
Newcastle disease (ND) has been recognized as one of the most devastating poultry diseasesworldwidel [1, 5, 7]. The disease has become an endemic disease in Taiwan since it was first reported in1951[15]. Major epidemisc occurred in Taiwan in 1969-1971,1984 [11] and in 1995. In these recentoutbreaks, the relaxation of vaccination programs has been blamed. However, some also suspected that NDvaccination programs once conferring good protection may not be adequate in recent outbreaks. It has beenreported that high maternal antibodies interfere with immune response of chicks to intranasal, intraocular,or oral routes of ND vaccination [4, 6, 9, 12]. In order to improve vaccination efficacy, vaccinationprograms composed of simultaneously inoculating chicks with live and inactivated ND vaccine gained35-13-2popularity in the field. However, few tests have been done to evaluate this kind of vaccination program. Inthis paper, several ND vaccination programs employing both live and inactivated ND vaccines wereevaluated.
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新城雞病免疫計畫保護效力之評估
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