篇名:
豬瘟免疫適期的探討Assessment of current hog cholera vaccination programs
作者:
黃天祥;鍾明華; 鄧明中; 王 ?; 林有良; 陳靜美; 黃金城
中文摘要:
檢測金門縣、台中縣和雲林縣等十一家養豬場之母豬和其小豬豬瘟疫苗免疫前後之豬瘟中和抗體力價結果,母豬之豬瘟免疫方式有三種,每種之豬瘟中和抗體幾何平均力價,每年免疫一次的四場為 605 倍,每半年免疫一次的四場為350倍,而基礎免疫三場中的二場為 260 倍。基礎免疫的另一豬場因曾是豬瘟污染場母豬抗體幾何平均力價為 1,399 倍,居十一場中之冠。小豬之豬瘟免疫方式則頗為多樣化,包括有哺乳前免疫、三週齡、五週齡、三和六週齡、五和八週齡免疫者各一場,以及六和九週齡、六和十二週齡、八和十二週齡免疫者各二場等八種免疫方式,惟每場小豬之豬瘟中和抗體幾何平均力價因移行抗體關係經一次或二次免疫後都有先降後升或呈持續上升兩種現象,顯示豬瘟疫苗的有效性。
英文摘要:
Serum samples were collected from sows and piglets prior to and post lapinized hog cholera vaccine(LPCV)vaccination of eleven pig farms located in Kinmen, Taichung and Yunlin counties, and were tested for serum neutralization antibody against hog cholera virus. Among the eleven pig farms, there were three vaccination programs for sows including four farms vaccinated once a year, four farms vaccinated once a half-year and three farms no more vaccination after the basic vaccination. The geometric means of serum neutralization antibody of sows were 1:605 for four farms vaccinated once a year, 1:350 for other four farms vaccinated once a half-year, 1:260 for another two farms basic vaccinated only, and 1:1,399 for a hog cholera contaminated farm that also performing basic vaccination. For piglets, there were eight different kinds of vaccination programs including five farms each performing vaccination prior to ingestion of colostrums, on 3 weeks, 5 weeks, 3 and 6 weeks, 5 and 8 weeks of age, respectively, and other 6 farms each two of them were vaccinated on 6 and 9 week, 6 and 12 weeks, 8 and 12 weeks of age. Depending on the level of colostrums antibody, the geometric means of piglets serum neutralization antibody titers of each farm showed decreased then increased or continue to increase after first shot or second vaccination.
備註:
年份:西元 2002 年
期別:第 38 期
詳細內容:
豬瘟(Hog cholera)是由豬瘟病毒(黃病毒科 Flaviviridae,瘟疫病毒屬Pestivirus)所引起豬隻的一種高度傳染性疾病,以全身性出血為主徵,死亡率高達 95-100%。病程,一般呈急性,但可轉為慢性或不顯性感染,增加防疫和診斷上的困擾〔13,20〕。 豬瘟係台灣豬隻重要法定傳染病之一,多年來影響養豬事業至鉅。由林博士再春等開發之兔化豬瘟疫苗,雖安全性高且免疫效力良好〔4〕,但四十餘年仍無法完全防止豬瘟的散發。此因受到人為因素、疫苗存放、免疫計畫不正確和移行抗體干擾、田間帶毒豬的存在以及對豬瘟病例未做適時處理等諸多因素的影響而使疫苗未能充分發揮其免疫效果。台灣小豬之豬瘟免疫適期,在 1979 年前採取六、九週齡兩次免疫注射〔3〕,但在 1979 年後賴等認為可能因豬假性狂犬病病毒(Pseudorabies virus)的普遍感染致使移行抗體的普遍降低,同時因養豬技術的提升而使仔豬離乳時間提前至四週齡,故而將小豬免疫計畫往前挪為三、六週齡免疫注射兩次〔14,15,16〕,而在 1980 年後為避免移行抗體干擾疫苗的免疫作用,後續推出哺乳前的免疫方式且一時間認為對於豬瘟污染場的效果良好〔17〕。至 1999年後農政單位將豬瘟免疫計畫酌予調整為,種母豬完成基礎免疫後,每年一次於空胎時免疫者,其所生仔豬分別約於第六週齡及第九週齡時各免疫一次;種母豬完成基礎免疫後,於配種前免疫一次,以後不再免疫者,其所生仔豬分別約於第三週齡及第六週齡時各免疫一次。唯田間應用上更為多樣化,致仍無法防止豬瘟的零星發生。
附件下載:
附件名稱:
豬瘟免疫適期的探討
行政院農業委員會家畜衛生試驗所版權所有
服務信箱:info@mail.nvri.gov.tw
Tel:0800-068112、02-26212111
FAX:02-2622-5345

免責聲明
 新北市淡水區中正路376號