篇名:
天竺鼠之飼養繁殖、供應與常見疾病Production and Supply of Guinea Pigs and Studies on common Diseases
作者:
林榮培;邱顯閔;梁奇鳳;林春基;蘇杰夫
中文摘要:
民國90 年2 月自國立台灣大學實驗動物中心分批引進天竺鼠(Hartley)共447隻(公125隻,母322隻),以乾淨傳統式(clean conventional)動物舍飼養。自民國90年3月份天竺鼠開始陸續生產,4月份開始供應,總生產隻數為1022隻天竺鼠。訂戶有中國醫藥學院等14個單位,供應配送方式係以空調貨運車運送動物至購買單位。於民國90年6月及11月分別送檢4隻及10隻天竺鼠至國家實驗動物繁殖及研究中心進行健康監測,6 月份檢查結果為:小鼠肺炎病毒(pneumonia virus of mouse, PVM) ELISA抗體檢測100%陽性反應(4/4),里奧病毒第三型(reovirus type 3, Reo-3) ELISA抗體檢測100%陽性反應(4/4);11月份檢查結果降為:PVM 抗體33.3%陽性反應(3/9), Reo-3抗體 22.2%陽性反應(2/9)。Bordetella bronchiseptica及Salmonella spp檢查皆為陰性。民國91年1月至12月生產供應各機關單位,總生產隻數為1397隻,供應810隻。訂戶計有中山醫學大學等13 個單位。於民國91 年6 月送檢9 隻天竺鼠至國家實驗動物繁殖及研究中心進行健康監測,檢查結果為:小鼠肺炎病毒 (PVM) ELISA 抗體檢測66.7% (6/9) 陽性反應,里奧病毒第三型 (Reo-3) ELISA抗體檢測66.7% (6/9) 陽性反應;12月份自行抗體檢查12隻,結果為:PVM 抗體42% (5/12) 陽性反應,Reo-3抗體 42% (5/12) 陽性反應。Bordetella bronchiseptica及Salmonella spp檢查也皆為陰性。
英文摘要:
The 447 guinea pigs in the National Taiwan University Laboratory Animal Center were transferred to Branch Institute for Animal Drugs Inspection (BIADI) for breeding and supply in February 2001. The guinea pig productivity was under clean conventional management, Of the 1022 born guinea pigs, the 525 postweaning guinea pigs (51.4﹪) were supplied between April and December. Using ELISA for serological monitor, PVM, Reo-3, Sendai, LCMV and SV-5 were detected in June and November, respectively. The result of antibodies detection in June was PVM 100﹪positive (4/4) and Reo-3 100﹪positive(4/4) , nevertheless, which was PVM 33.3﹪positive (3/9)and Reo-3 22.2 ﹪positive(2/9) in November. At necropsy, the interstitial, non-suppurate pneumonia with syncytial cell formation and lymphatic perivascular cuffing was found as the major pathological features, in addition, the fatty change, alopecia and metritis were also observed in some cases. The Bordetella bronchiseptica and Salmonella spp were also inspected as important monitored-pathogens, and the result was negative. Under clean conventional management, 1397 new guinea pigs were produced, in which 810 postweaning guinea pigs (58﹪) were supplied to laboratories in 2002. Serological monitor with ELISA on antibodies against PVM, Reo-3, Sendai, LCMV and SV-5 were performed in June and December 2002. The results showed that 66.7% (6/9) of animals were seropositive to PVM and 66.7﹪(6/9) to Reo-3 in June. Then, in December the positive rate of PVM was 42﹪(5/12) and of Reo-3 was 42﹪(5/12). However, the Sendai, LCMV and SV-5 were negative.
備註:
年份:西元 2004 年
期別:第 40 期
詳細內容:
實驗動物在生命科學領域扮演重要角色,無論是基礎研究或應用方面均需實驗動物供作實驗材料,方能促進醫藥衛生及生物技術的進步。天竺鼠在研究上的使用雖不如小鼠、大鼠之重要及普遍,但仍在一些領域扮演舉足輕重的地位,如營養學(尤其是維他命C缺乏症)探討,因組織胺釋放引起的氣管痙(Bronchospasm)、過敏性休克(Anaphylactic shock)研究,血清補體(serum complement)之探討;而天竺鼠的聽力範圍與耳構造與人類十分類似,故在人醫的耳科學研究相當重要;此外,由於其賀爾蒙變化對懷孕的影響與人類相似,亦有動物模式的應用研究(1,2,6) 。在獸醫方面,口蹄疫之研究、疫苗之檢定等也需要應用天竺鼠。目前國內供應實驗動物的單位計有國家實驗動物繁殖及研究中心、台大、成大、慈濟、國防、陽明及本分所等,其間所形成的實驗動產銷系統雖具雛形,但彼此間之協調聯繫步驟較為鬆散,藉由國科會之天竺鼠之生產與供應委託計劃,由本分所生產供應品質優良之天竺鼠,達成整體性、連貫性 ” 分工合作”之成效,以期能供應國內各研究機構實驗所需,提昇國內相關研究水準。
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